Search our team at AdventHealth Research Institute
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NCT06065748
A Phase III Randomized, Open-Label Study Evaluating Efficacy and Safety of Giredestrant Compared With Fulvestrant, Both Combined With a CDK4/6 Inhibitor, in Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer With Resistance to Prior Adjuvant Endocrine Therapy (pionERA Breast Cancer)
This study is not currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Altamonte, FloridaThe purpose of this study is to compare the effects, good or bad, of two hormonal treatments, giredestrant and fulvestrant, both given in combination with your study doctor’s choice of a class of...
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NCT06676072
Safety and effectiveness of the TactiFlex SE Catheter and Volt Pulsed Field Ablation (PFA) Generator in subjects with paroxysmal atrial fibrillation
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe purpose of the study is to find out if the investigational TactiFlex PFA System, the device that is being studied, is safe and effective in treating adults like you who have atrial fibrillation
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Specimen Collection for the Study of Solid Tumors and Other Diseases
This study is not currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Shawnee Mission, KansasWe are collecting these samples to study diseases such as cancer, heart disease, musculoskeletal disease (bones and joints), blood disease (such as leukemia, lymphoma and multiple myeloma [cancer of...
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NCT06400342
The REVIVE-TAVR (Randomized Evaluation of Valve-In-Valve versus Explantation for failed Transcatheter Aortic Valve Replacement)
This study is not currently enrolling.Research Area: Heart, Lung and Vascular Research -
Retrospective Data Collection of Ultrasound Media from Subjects Implanted with Impella® Device
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Tampa, Florida -
NCT06456463
A Phase II multicenter open-label trial of tagraxofusp (Tag) in combination with venetoclax and azacitidine (Ven/Aza) in adults with previously untreated CD123+ acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy.
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer Research -
External Evaluation Plan: User Evaluation of the Next Generation CardioLab EP Recording System with the Prucka 3 Digital EP Amplifier
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Celebration, FloridaThe current CardioLab system is cleared by the FDA for use on patients of all ages when a physician determines that a patient would benefit from an electrophysiology procedure. CardioLab can be used...
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Evaluating the Efficacy of the Full Plate Living Program: A Cardiology Clinic-based Intervention in Winter Park, FL
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Winter Park, FloridaThe primary objective of this study is to evaluate the impact of the Full Plate Living Program, developed by the Ardmore Institute of Health, on patient nutrition knowledge, diet, and lifestyle. The...
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NCT06131372
NN9388-7700: Efficacy and safety of co-administered cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (cagrisema s.c. 2.4 mg/2.4 mg) once-weekly compared to semaglutide, cagrilinitide and placebo in people with chronic kidney disease and type 2 diabetes.
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this study is to see whether CagriSema can lower kidney damage. This will be compared to the effects of semaglutide, cagrilintide and placebo.
Study Duration...
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NCT05845710
Protection against Emboli during caRotid artery stenting using a Neuroguard IEP® Direct 3-in-1 delivery system comprised oF a pOstdilation balloon, integRated eMbolic filter, and A Novel Carotid stEnt III
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaTo evaluate the safety and effectiveness of direct carotid access for stenting using
the Neuroguard IEP Direct System in subjects at high risk for carotid
endarterectomy who require carotid... -
NCT06081894
A PHASE 3, MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF AFICAMTEN COMPARED TO PLACEBO IN ADULTS WITH SYMPTOMATIC NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY Department #: 407-303-7556
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe purpose of this study is to compare the effects of aficamten and placebo on health status and exercise capacity in participants with nHCM. The safety and tolerability of aficamten at different...
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NCT06188559
BB-1701-G000-205 An Open-label, Multicenter, Phase 2 Dose Optimization and Expansion Study to Evaluate the Safety and Efficacy of BB-1701, an anti-human epidermal growth factor receptor 2 (anti-HER2) antibody-drug conjugate (ADC), in Previously Treated Subjects with HER2-positive or HER2-low Unresectable or Metastatic Breast Cancer
This study is not currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to determine if a new drug called BB-1701 is safe and effective in people who have HER2-positive or HER2-low, unresectable or metastatic breast cancer (MBC). There are two...