Clinical Trials

• NCT05705401

  A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO)

  This study is not currently enrolling.

  Associated Conditions: Breast Cancer

  Research Area: Clinical Cancer Research

• CLEE011O12001 A phase IIIb study to characterize the effectiveness and safety of Adjuvant ribociclib in a wide patient population with HR+ HER2- early breast cancer (Adjuvant WIDER)

  This study is not currently enrolling.

  Associated Conditions: Breast Cancer

  Research Area: Clinical Cancer Research

• A Randomized Phase 2b/Phase 3 Study of the TGF-β2 Targeting Antisense Oligonucleotide OT-101 in Combination with mFOLFIRINOX Compared with mFOLFIRINOX Alone in Patients with Advanced and Unresectable or Metastatic Pancreatic Cancer

  This study is not currently enrolling.

  Associated Conditions: Colorectal Cancer

  Research Area: Clinical Cancer Research
• NCT04724018

  DF/HCC 20-614 Combinatons of Sacituzumab govitecan plus enfortumab vedotin and pembrolizumab for metastatic urothelial carcinoma: the Double Antibody Drug conjugate (DAD) and Double Antibody Drug Conjugate with Immunotherapy (DAD-IO) Phase I/II trial

  This study is not currently enrolling.

  Associated Conditions: Urothelial Cancer

  Research Area: Clinical Cancer Research

• A global Phase 3, open label, Randomized Study of CB-010, a CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy vs the standard of care treatment in adult patients with high-risk, transplant-eligible Relapsed/Refractory Large B Cell Non-Hodgkin Lymphoma (ANTLER-Phase 3 [Part III])

  This study is not currently enrolling.

  Associated Conditions: Bone Cancer

  Research Area: Clinical Cancer Research

• A Phase 2/3 randomized study of a Raludotatug Deruxtecan (R-DXd), a CDH6-directed Antibody-drug Conjugate, in Subjects with Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancers

  This study is not currently enrolling.

  Research Area: Clinical Cancer Research
• NCT06469944

  A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents with Pembrolizumab (MK-3475) in Participants with Advanced Esophageal Cancer naïve to PD-1/PD-L1 Treatment [KEYMAKER-U06]

  This study is not currently enrolling.

  Associated Conditions: Esophageal Cancer

  Research Area: Clinical Cancer Research

• Enzatamide plus Lutetium-PSMA as neoadjuvant therapy preceding radical prostatectomy for high risk localized/locally advanced prostate cancer: a Phase I/Ib trial

  This study is not currently enrolling.

  Associated Conditions: Prostate Cancer

  Research Area: Clinical Cancer Research
• NCT05900908

  A Randomized Controlled Trial of Surgical Resection with GammaTile Therapy and Adjuvant Systemic Therapy compared to Surgical Resection and Adjuvant Systemic Therapy at first recurrence in Glioblastoma.

  This study is not currently enrolling.

  Associated Conditions: Brain Cancer

  Research Area: Clinical Cancer Research
• NCT05633654

  GS-US-595-6184 A Randomized, Open-label, Phase 3 Study of Adjuvant Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/NSABP B-63; NCT05633654)

  This study is not currently enrolling.

  Associated Conditions: Breast Cancer

  Research Area: Clinical Cancer Research

• Deep-learning of digital histopathology, radiomics and clinical factors to develop precision medicine with first-line gemcitabine-cisplatin-nivolumab for metastatic urothelial carcinoma: analysis of the CHECKMATE901 Phase III trial

  This study is not currently enrolling.

  Associated Conditions: Urothelial Cancer

  Research Area: Clinical Cancer Research
• NCT04585750

  A Phase 1/2 Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of PC14586 in Patients With Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

  This study is not currently enrolling.

  Research Area: Clinical Cancer Research